Article
Mitochondrial processing of bovine adrenal steroidogenic acute regulatory protein.
Biochimica et biophysica acta - 1 Oct 2006
Yamazaki Takeshi, Matsuoka Chisa, Gendou Miho, Izumi Shunsuke, Zhao Dong, Artemenko Irina, Jefcoate Colin R, Kominami Shiro
Abstract excerpt
Steroidogenic acute regulatory (StAR) protein is an important regulatory protein in steroidogenesis and rapidly undergoes proteolysis after import into the mitochondria. In this study, we determined the proteolytic cleavage sites and investigated the effects on the stimulation of steroidogenic activity of the blockage of these sites by mutation. The cleaved StAR proteins, which were purified using an anti-StAR...
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