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Article

Application of two neutral MspI DNA polymorphisms in the analysis of hereditary protein C deficiency.

Thrombosis and haemostasis - 22 Oct 1990

Reitsma P H, te Lintel Hekkert W, Koenhen E, van der Velden P A, Allaart C F, Deutz-Terlouw P P, Poort S R, Bertina R M

Abstract excerpt

Screening of restriction enzyme digested DNA from normal and protein C deficient individuals with a variety of probes derived from the protein C locus has revealed the existence of two neutral MspI polymorphism. One polymorphism (MI), which is located approximately 7 kb upstream of the protein C gene, has allelic frequencies of 69 and 31%, and was used to exclude extensive gene deletions as a likely cause of type...

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PMID: 1702905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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