Article
Typing of MNSs blood group specific sequences in the human genome and characterization of a restriction fragment tightly linked to S-s- alleles.
Blood - 15 Jan 1991
Huang C H, Guizzo M L, McCreary J, Leigh E M, Blumenfeld O O
Abstract excerpt
Human erythrocyte membrane alpha and delta glycophorins (glycophorins A and B) carry the antigens for the M,N,S,s blood group system. Synthetic oligonucleotides spanning coding regions for M,N,S, and s epitopes were used to examine DNAs from 50 individuals selected at random and from individuals known to exhibit S(-)s(-)U- or S(-)s(-)U+ blood group phenotypes. We showed that M,N,S,s, blood group-specific...
Topics
- Alleles
- Black People
- Chromosome Mapping
- Deoxyribonuclease HpaII
- Deoxyribonucleases, Type II Site-Specific
- Glycophorins
- Humans
- MNSs Blood-Group System
- Oligonucleotide Probes
- Polymerase Chain Reaction