Article
Rapid molecular characterization of Hb Queens and Hb Siam: two variants easily misidentified as sickle Hb.
Clinical biochemistry - 1 Jan 2007
Fucharoen Supan, Singsanan Sanita, Hama Abdulloh, Fucharoen Goonnapa, Sanchaisuriya Kanokwan
Abstract excerpt
OBJECTIVE: To establish a rapid differential diagnosis of hemoglobin (Hb) Queens and Hb Siam from other clinically relevant variants. DESIGN AND METHODS: Molecular and hematological features associated with two pregnant Thai women who were mistaken for Hb S were investigated. A simultaneous DNA diagnosis based on multiplex allele specific PCR approach was developed and tested with other common variants. RESULTS:...
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