Inhibition of Endothelial Cell Proliferation, In Vitro Angiogenesis, and the Down-Regulation of Cell Adhesion–Related Genes by Genistein Combined with a cDNA Microarray Analysis

Abstract excerpt

Antiangiogenesis is presently one of the powerful strategies for treating cancer, and endothelial cells play a pivotal role in the process of angiogenesis. Genistein, a tyrosine kinase inhibitor, a major isoflavone plentiful in soybeans, is known to inhibit both tumor growth and angiogenesis. However, the precise molecular mechanism(s) by which genistein affects endothelial cells has yet to be elucidated. In the...

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