Article
Antenatal screening and fetal diagnosis of beta-thalassemia in a Chinese population: prevalence of the beta-thalassemia trait in the Guangzhou area of China.
Human genetics - 1 Aug 1996
Xu X, Liao C, Liu Z, Huang Y, Zhang J, Li J, Peng Z, Qiu L, Xu Q
Abstract excerpt
In this paper beta-globin gene mutations were detected in 452 beta-thalassemia carriers from 13462 unselected individuals (6731 pregnant women and their husbands) who were screened for the beta-thalassemia trait in the Guangzhou area of China. The incidence of beta-thalassemia was calculated as 3.36%. This is higher than found in previous studies performed in southern China. Using reverse dot blot analysis, we...
Topics
- Amino Acid Sequence
- Base Sequence
- China
- DNA
- Female
- Genetic Testing
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Pregnancy
- Prenatal Diagnosis