Article
Concordance of functional in vitro data and epidemiological associations in complex disease genetics.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Sept 2006
Ioannidis John P A, Kavvoura Fotini K
Abstract excerpt
PURPOSE: We aimed to assess whether epidemiological evidence on genetic associations for complex diseases concord with in vitro functional data. METHODS: We examined 36 studies on bi-allelic markers and 23 studies on haplotypes where investigators had addressed both epidemiological associations and the functional effect of the same gene variants in luciferase reporter systems in vitro. RESULTS: There was no...
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