Article
Mutations in the MYB intron I regulatory sequence increase transcription in colon cancers.
Genes, chromosomes & cancer - 1 Dec 2006
Hugo Honor, Cures Alina, Suraweera Nirosha, Drabsch Yvette, Purcell Damian, Mantamadiotis Theo, Phillips Wayne, Dobrovic Alex, Zupi Gabriella, Gonda Thomas J, Iacopetta Barry, Ramsay Robert G
Abstract excerpt
Although MYB overexpression in colorectal cancer (CRC) is known to be a prognostic indicator for poor survival, the basis for this overexpression is unclear. Among multiple levels of MYB regulation, the most dynamic is the control of transcriptional elongation by sequences within intron 1. The authors have proposed that this regulatory sequence is transcribed into an RNA stem-loop and 19-residue polyuridine...
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