Co-expression of the genes encoding transforming growth factor-alpha and its receptor in papillary carcinomas of the thyroid.

doi:10.1002/ijc.2910460308

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Article

Co-expression of the genes encoding transforming growth factor-alpha and its receptor in papillary carcinomas of the thyroid.

International journal of cancer - 15 Sept 1990

Aasland R, Akslen L A, Varhaug J E, Lillehaug J R

Abstract excerpt

Transforming growth factor-alpha (TGF-alpha) is frequently coexpressed with its receptor, epidermal growth factor receptor (EGF-R), in several types of carcinoma and sarcoma. It is believed that this results in an autocrine stimulation of tumor growth in these tumors. We have found that TGF-alpha and EGF-R/c-erbB RNAs were co-expressed at significantly higher levels in papillary thyroid carcinomas and their...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Carcinoma, Papillary
ErbB Receptors
Female
Genes, Neoplasm
Humans
Lymphatic Metastasis
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Proteins

Nucleic Acid Hybridization

Phenotype

RNA

Thyroid Neoplasms

Transforming Growth Factors

Source

Open in PubMed

Identifiers

PMID: 1697567
DOI: 10.1002/ijc.2910460308

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1697567-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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