Article
Co-expression of the genes encoding transforming growth factor-alpha and its receptor in papillary carcinomas of the thyroid.
International journal of cancer - 15 Sept 1990
Aasland R, Akslen L A, Varhaug J E, Lillehaug J R
Abstract excerpt
Transforming growth factor-alpha (TGF-alpha) is frequently coexpressed with its receptor, epidermal growth factor receptor (EGF-R), in several types of carcinoma and sarcoma. It is believed that this results in an autocrine stimulation of tumor growth in these tumors. We have found that TGF-alpha and EGF-R/c-erbB RNAs were co-expressed at significantly higher levels in papillary thyroid carcinomas and their...
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