Article
Atypical mutational properties of human chromosome 21 suggested by comparative genome-scale analyses.
Cytogenetic and genome research - 1 Jan 2006
Vieira A
Abstract excerpt
Mutation of genetic material is a necessary component of evolutionary change. There is evidence for both intragenome and intergenome heterogeneity in terms of mutation frequencies. Reported comparisons of DNA sequence differences between human and chimpanzee (Pan troglodytes) suggest that human chromosome 21 may exhibit mutational hypervariability relative to the other autosomes. In the present study, further...
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