Article
Divergence of the genes on human chromosome 21 between human and other hominoids and variation of substitution rates among transcription units.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jul 2003
Shi Jinxiu, Xi Huifeng, Wang Ying, Zhang Chenghui, Jiang Zhengwen, Zhang Kuixing, Shen Yayun, Jin Lin, Zhang Kaiyue, Yuan Wentao, Wang Ying, Lin Jie, Hua Qi, Wang Fengqing, Xu Shuhua, Ren Suangxi, Xu Shijie, Zhao Guoping, Chen Zhu, Jin Li, Huang Wei
Abstract excerpt
The study of genomic divergence between humans and primates may provide insight into the origins of human beings and the genetic basis of unique human traits and diseases. Chromosome 21 is the smallest chromosome in the human genome, and some of its regions have been implicated in mental retardation and other diseases. In this study, we sequenced the coding and regulatory regions of 127 known genes on human...
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