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Article

Detection of point mutations in type I collagen by RNase digestion of RNA/RNA hybrids.

Nucleic acids research - 25 Jul 1990

Grange D K, Gottesman G S, Lewis M B, Marini J C

Abstract excerpt

We have developed a strategy for the detection, localization and sequence determination of point mutations in the mRNA coding for the alpha 1(I) and alpha 2(I) chains of type I collagen. Point mutations are detected by RNase A cleavage of mismatches in RNA/RNA hybrids. The mRNAs coding for the fibrillar collagens present special problems for hybrid analysis because of their large size and their GC-rich and...

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Identifiers

PMID: 1696002
DOI: 10.1093/nar/18.14.4227
PMCID: PMC331183

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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