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Article

Depletion of mitochondrial DNA in leucocytes harbouring the 3243A→G mtDNA mutation

1 Sept 2006

Abstract excerpt

BACKGROUND: The 3243A-->G MTTL1 mutation is the most common heteroplasmic mitochondrial DNA (mtDNA) mutation associated with disease. Previous studies have shown that the percentage of mutated mtDNA decreases in blood as patients get older, but the mechanisms behind this remain unclear. OBJECTIVES AND METHOD: To understand the dynamics of the process and the underlying mechanisms, an accurate fluorescent assay...

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PMID: 16950816
DOI: 10.1136/jmg.2006.043109

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