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Article

Effects of rapamycin on accumulation of <i>α</i>‐, <i>β</i>‐ and <i>γ</i>‐globin mRNAs in erythroid precursor cells from <i>β</i>‐thalassaemia patients

24 Aug 2006

Abstract excerpt

We studied the effects of rapamycin on cultures of erythroid progenitors derived from the peripheral blood of 10 beta-thalassaemia patients differing widely with respect to their potential to produce foetal haemoglobin (HbF). For this, we employed the two-phase liquid culture procedure for growing erythroid progenitors, high performance liquid chromatography for analysis of HbF production and reverse...

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PMID: 16939628
DOI: 10.1111/j.1600-0609.2006.00731.x

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