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Article

Efficacy of Rapamycin as Inducer of Hb F in Primary Erythroid Cultures from Sickle Cell Disease and β-Thalassemia Patients.

Hemoglobin - 1 Jan 2015

Pecoraro Alice, Troia Antonio, Calzolari Roberta, Scazzone Concetta, Rigano Paolo, Martorana Adriana, Sacco Massimiliano, Maggio Aurelio, Di Marzo Rosalba

Abstract excerpt

Phenotypic improvement of hemoglobinopathies such as sickle cell disease and β-thalassemia (β-thal) has been shown in patients with high levels of Hb F. Among the drugs proposed to increase Hb F production, hydroxyurea (HU) is currently the only one proven to improve the clinical course of these diseases. However, Hb F increase and patient's response are highly variable, indicating that new pharmacological agents...

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Identifiers

PMID: 26016899
DOI: 10.3109/03630269.2015.1036882

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Efficacy of Rapamycin as Inducer of Hb F in Primary Erythroid Cultures from Sickle Cell Disease and β-Thalassemia Patients.PMID 26016899Read ↗

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