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Article

EBV latent membrane protein 2A induces autoreactive B cell activation and TLR hypersensitivity.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2006

Wang Hongsheng, Nicholas Matilda W, Conway Kara L, Sen Pradip, Diz Ramiro, Tisch Roland M, Clarke Stephen H

Abstract excerpt

EBV is associated with systemic lupus erythematosus (SLE), but how it might contribute to the etiology is not clear. Since EBV-encoded latent membrane protein 2A (LMP2A) interferes with normal B cell differentiation and function, we sought to determine its effect on B cell tolerance. Mice transgenic for both LMP2A and the Ig transgene 2-12H specific for the ribonucleoprotein Smith (Sm), a target of the immune...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16920914
DOI: 10.4049/jimmunol.177.5.2793

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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