Article
Allodeterminants and evolution of a novel HLA-B5 CREG antigen, HLA-B SNA.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 1990
Sekimata M, Hiraiwa M, Andrien M, Dupont E, Karaki S, Yamamoto J, Kano K, Takiguchi M
Abstract excerpt
A novel HLA-B5 CREG gene, HLA-B SNA was cloned and the primary structure was determined. The sequence data showed that HLA-B SNA was identical to HLA-B51 except the alpha 1 domain in which one amino acid substitution at residue 74 and 5 amino acid substitutions associated with the Bw4/Bw6 epitopes were observed between these Ag. The comparison with other HLA-B locus genes suggested that HLA-B SNA evolved from...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- Biological Evolution
- Cloning, Molecular
- Cross Reactions
- Epitopes
- Genes
- HLA-B Antigens
- Humans
- Immunity, Cellular