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Article

Molecular analysis of the CLCNKB gene in Japanese patients with classic Bartter syndrome.

Endocrine journal - 1 Oct 2006

Tajima Toshihiro, Nawate Mitsuru, Takahashi Yutaka, Mizoguchi Yumiko, Sugihara Shigetaka, Yoshimoto Masaaki, Murakami Mutsumi, Adachi Masanori, Tachibana Katsuhiko, Mochizuki Hiroshi, Fujieda Kenji

Abstract excerpt

Deletions or mutations in the gene encoding the basolateral chloride channel CLC-Kb (CLCNKB) cause classic Bartter syndrome (MIM 602023), which is characterized by hypokalemic metabolic alkalosis, hyperreninemic hyperaldosteronism and hypercalciura. These patients are usually diagnosed during infancy or childhood due to failure to thrive and growth retardation. The purpose of this study was to investigate the...

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Source

Identifiers

PMID: 16902263
DOI: 10.1507/endocrj.k06-034

Genes

CLCNKB
CLC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Molecular analysis of the CLCNKB gene in Japanese patients with classic Bartter syndrome.PMID 16902263Read ↗

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ClC-K chloride channels: emerging pathophysiology of Bartter syndrome type 3.Semantic proximity Read ↗

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