Specific phenotyping of T-cell proliferations in formalin-fixed paraffin-embedded tissues. Use of antibodies to the T-cell receptor beta F1.

doi:10.1093/ajcp/93.3.382

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Article

Specific phenotyping of T-cell proliferations in formalin-fixed paraffin-embedded tissues. Use of antibodies to the T-cell receptor beta F1.

American journal of clinical pathology - 1 Mar 1990

Said J W, Shintaku I P, Parekh K, Pinkus G S

Abstract excerpt

Antibody beta F1 to a common framework determinant of the beta subunit of the T-cell receptor (TCR) was used as a specific phenotypic marker for T-cell differentiation in malignant lymphomas. Sensitivity of immunoperoxidase staining in paraffin sections was enhanced by pronase pretreatment, overnight incubation of primary antibody in Tween 20, and use of streptavidin horseradish peroxidase complexes to amplify...

Topics

Antibody Specificity
Antigens, Differentiation, B-Lymphocyte
Antigens, Differentiation, T-Lymphocyte
Biomarkers, Tumor
Cell Division
Epitopes
Evaluation Studies as Topic
Formaldehyde
Humans
Immunoenzyme Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphoma

Paraffin

Phenotype

Receptors, Interleukin-2

Staining and Labeling

T-Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 1689944
DOI: 10.1093/ajcp/93.3.382

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1689944-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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