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Article

Modest phenotypic improvements in ASA-deficient mice with only one UDP-galactose:ceramide-galactosyltransferase gene.

Lipids in health and disease - 7 Aug 2006

Franken S, Wittke D, Mansson J E, D'Hooge R, De Deyn P P, Lüllmann-Rauch R, Matzner U, Gieselmann V

Abstract excerpt

BACKGROUND: Arylsulfatase A (ASA)-deficient mice are a model for the lysosomal storage disorder metachromatic leukodystrophy. This lipidosis is characterised by the lysosomal accumulation of the sphingolipid sulfatide. Storage of this lipid is associated with progressive demyelination. We have ma...

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Identifiers

PMID: 16893448
DOI: 10.1186/1476-511X-5-21
PMCID: PMC1564137

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16893448-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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