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Article

Early signs of neurolipidosis-related behavioural alterations in a murine model of metachromatic leukodystrophy.

Behavioural brain research - 3 Jun 2008

Stroobants Stijn, Leroy Toon, Eckhardt Matthias, Aerts Jean-Marie, Berckmans Daniel, D'Hooge Rudi

Abstract excerpt

Arylsulfatase A (ASA)-deficient mice represent an animal model for the lysosomal storage disorder metachromatic leukodystrophy (MLD). Although the model has been applied in pathophysiological and therapeutic studies, the behavioural phenotype of ASA(-/-) mice is only partially characterized, and the most decisive outcome measures for therapy evaluation only emerge beyond 1 year of age. Presently, ASA(-/-) mice...

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Source

Identifiers

PMID: 18336930
DOI: 10.1016/j.bbr.2008.01.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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