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Article

Combined mutations of canalicular transporter proteins cause severe intrahepatic cholestasis of pregnancy.

Gastroenterology - 1 Aug 2006

Keitel Verena, Vogt Christoph, Häussinger Dieter, Kubitz Ralf

Abstract excerpt

Intrahepatic cholestasis of pregnancy (ICP) is a cholestatic disorder that usually develops in the third trimester of pregnancy and persists until delivery. The cause of ICP remains elusive, but there is evidence that mutations in the canalicular ABC transporter phospholipid flippase (MDR3) and in the bile salt export pump (BSEP) can predispose for the development of ICP. MDR3 and BSEP were investigated by gene...

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to ATP Binding Cassette Transporter, Subfamily B, Member 11

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cholestasis, Intrahepatic

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Share to Pregnancy Trimester, Third

Source

Identifiers

PMID: 16890614
DOI: 10.1053/j.gastro.2006.05.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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