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Article

Evaluation of FOXC2 as a candidate gene for chronic progressive lymphedema in draft horses.

Veterinary journal (London, England : 1997) - 1 Sept 2007

Young Amy E, Bower Leslie P, Affolter Verena K, De Cock Hilde E V, Ferraro Gregory L, Bannasch Danika L

Abstract excerpt

Chronic progressive lymphedema (CPL) is a debilitating condition identified in Clydesdales, Shires and Belgian draft horses and results in progressive swelling of the lower legs associated with the development of thick skin folds, ulcerations, fibrosis and marked hyperkeratosis. The result is severe discomfort and recurrent secondary infection, often requiring euthanasia. Due to the delayed onset, many horses are...

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Source

Identifiers

PMID: 16884936
DOI: 10.1016/j.tvjl.2006.05.023

Genes

FOXC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Evaluation of FOXC2 as a candidate gene for chronic progressive lymphedema in draft horses.PMID 16884936Read ↗

Whole-genome scan identifies quantitative trait loci for chronic pastern dermatitis in German draft horses.Semantic proximity Read ↗

A mutation in the LAMC2 gene causes the Herlitz junctional epidermolysis bullosa (H-JEB) in two French draft horse breeds.Semantic proximity Read ↗

Chronic progressive lymphoedema in Friesian horses: suggestive phenotype of affected horses and genome-wide association study.Semantic proximity Read ↗

Foxc2 is expressed in developing lymphatic vessels and other tissues associated with lymphedema-distichiasis syndrome.Semantic proximity Read ↗

Analysis of lymphoedema-distichiasis families for FOXC2 mutations reveals small insertions and deletions throughout the gene.Semantic proximity Read ↗

Mutations in FOXC2 (MFH-1), a forkhead family transcription factor, are responsible for the hereditary lymphedema-distichiasis syndrome.Semantic proximity Read ↗

Analysis of the phenotypic abnormalities in lymphoedema-distichiasis syndrome in 74 patients with FOXC2 mutations or linkage to 16q24.Semantic proximity Read ↗

Truncating mutations in FOXC2 cause multiple lymphedema syndromes.Semantic proximity Read ↗

Novel FOXC2 Mutation and Distichiasis in a Patient With Lymphedema-Distichiasis Syndrome.Semantic proximity Read ↗

Literature watch. FOXC2 haploinsufficient mice are a model for human autosomal dominant lymphedema-distichiasis syndrome.Semantic proximity Read ↗

Prevalence of the mutation in cyclophilin B (PPIB), a causal candidate gene for HERDA, among Quarter Horses in France.Semantic proximity Read ↗

A Gene for Lymphedema-Distichiasis Maps to 16q24.3Semantic proximity Read ↗

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