Article
Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients.
Acta pharmacologica Sinica - 1 Aug 2006
Wu Sheng-Nan, Gao Rui, Xing Qing-He, Li Hua-Fang, Shen Yi-Feng, Gu Niu-Fan, Feng Guo-Yin, He Lin
Abstract excerpt
AIM: Extrapyramidal syndrome (EPS) is most commonly affected by typical antipsychotic drugs that have a high affinity with the D2 receptor. Recently, many research groups have reported on the positive relationship between the genetic variations in the DRD2 gene and the therapeutic response in schizophrenia patients as a result of the role of variations in the receptor in modulating receptor expression. In this...
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