The FAD-Dependent Tricarballylate Dehydrogenase (TcuA) Enzyme of <i>Salmonella enterica</i> Converts Tricarballylate into <i>cis</i> -Aconitate

Abstract excerpt

Tricarballylate is the causative agent of grass tetany, a ruminant disease characterized by acute magnesium deficiency. Tricarballylate toxicity has been attributed to its ability to chelate magnesium and to inhibit aconitase, a Krebs cycle enzyme. Neither the ruminant nor the normal rumen flora can catabolize tricarballylate to ameliorate its toxic effects. However, the gram-negative enterobacterium Salmonella...

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