Article
The Respiratory Pathogen<i>Moraxella catarrhalis</i>Binds to Laminin via Ubiquitous Surface Proteins A1 and A2
25 Jul 2006
Abstract excerpt
Moraxella catarrhalis is one of the leading causes of exacerbations in chronic obstructive pulmonary disease (COPD). In the present article, we show that moraxella (n=15) binds to the major basement-membrane glycoprotein laminin, which is thickened in the airways of smokers. Using clinical strains of M. catarrhalis and their corresponding ubiquitous surface protein (Usp) A1/A2 mutants, we demonstrate that UspA1...
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