Article
C-terminal arginine cluster is essential for receptor binding of norovirus capsid protein.
Journal of virology - 1 Aug 2006
Tan Ming, Meller Jarek, Jiang Xi
Abstract excerpt
Noroviruses are the major viral pathogens of epidemic acute gastroenteritis affecting people worldwide. They have been found to recognize human histo-blood group antigens as receptors. The P domain of norovirus capsid protein was found to be responsible for binding to viral receptors, and the recombinant P protein forms P dimers and P particles in vitro. In this study, we demonstrate that a highly conserved...
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