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Article

Cell expression of a four extra octarepeat mutated PrPC modifies cell structure and cell cycle regulation.

FEBS letters - 24 Jul 2006

Martín Sergio F, Herva María E, Espinosa Juan-Carlos, Parra Beatriz, Castilla Joaquín, Brun Alejandro, Torres Juan M

Abstract excerpt

RK13 cell lines generated to express bovine PrP(C) with a four extra octarepeat insertional mutation (Bo-10ORPrP(C)) show partially insoluble PrP(C) and lower rates of cell growth when compared to either the same cells expressing wild type Bo-6ORPrP(C) or the original RK13 cell line. The expression of Bo-10ORPrP(C) in cell cultures was also associated with changes in cell size and reorganization of the actin...

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Identifiers

PMID: 16828087
DOI: 10.1016/j.febslet.2006.06.054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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