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Article

Mapping of the von Hippel-Lindau disease locus to a small region of chromosome 3p by genetic linkage analysis.

Genomics - 1 Aug 1991

Maher E R, Bentley E, Yates J R, Latif F, Lerman M, Zbar B, Affara N A, Ferguson-Smith M A

Abstract excerpt

Genetic linkage studies were performed in 22 families with von Hippel-Lindau (VHL) disease by using polymorphic DNA markers from distal chromosome 3p. Linkage was detected between VHL disease and the markers D3S18 (Zmax = 6.6 at theta = 0.0, confidence interval (CI) 0.00-0.06), RAF1 (Zmax = 5.9 at theta = 0.06, CI 0.01-0.16), and THRB (Zmax 3.4 at theta = 0.11). Multipoint linkage analysis localized the VHL...

Topics

Adrenal Gland Neoplasms
Blotting, Southern
Chromosome Mapping
Chromosomes, Human, Pair 3
DNA
Family
Genetic Linkage
Genetic Markers
Genetic Predisposition to Disease
Humans
Lod Score

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pheochromocytoma

Polymorphism, Restriction Fragment Length

von Hippel-Lindau Disease

Source

Identifiers

PMID: 1680799
DOI: 10.1016/0888-7543(91)90185-h

Genes

VHL
RAF1
THRB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1680799-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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