Article
Adenylyl cyclases in oocyte maturation: A characterization of AC isoforms in bovine cumulus cells
27 Jun 2006
Abstract excerpt
Mammalian oocytes are arrested at the G(2)/M transition in the meiotic cell cycle. It is well known that a decrease in intraoocyte cAMP concentrations accompanies resumption of meiosis, but the precise trigger of this decrease remains a mystery. Follicular somatic cells are intimately coupled to the oocyte and are thought to transmit maturation signals to the oocyte in response to hormonal stimulation. Here, we...
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