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Article

The effects of multiple ancestral residues on the Thermus thermophilus 3-isopropylmalate dehydrogenase.

FEBS letters - 10 Jul 2006

Watanabe Keiko, Yamagishi Akihiko

Abstract excerpt

Previously, we showed that mutants of Thermus thermophilus 3-isopropylmalate dehydrogenase (IPMDH) each containing a residue (ancestral residue) that had been predicted to exist in a postulated common ancestor protein often have greater thermal stabilities than does the contemporary wild-type enzyme. In this study, the combined effects of multiple ancestral residues were analyzed. Two mutants, containing multiple...

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Source

Identifiers

PMID: 16797545
DOI: 10.1016/j.febslet.2006.06.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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