Article
No association of vacuolar protein sorting 26 polymorphisms with Alzheimer's disease.
Neurobiology of aging - 1 Jun 2007
Riemenschneider M, Schoepfer-Wendels A, Friedrich P, Konta L, Laws S M, Mueller J C, Kurz A, Förstl H
Abstract excerpt
Using a case-control sample we evaluated a possible involvement of the Vacuolar protein sorting 26 (VPS26) gene in the pathogenesis of AD. VPS26 located at 10q22.1 denotes a retromer subunit functionally involved in the cellular trafficking of Memapsin 2 (BACE). Genotyping of eight single nucleotide polymorphisms covering the complete VPS26 gene and haplotypic analysis revealed no association with AD. Thus, we...
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