Article
Generation of variability at VNTR loci in human DNA.
EXS - 1 Jan 1991
Wolff R, Nakamura Y, Odelberg S, Shiang R, White R
Abstract excerpt
Our laboratory has constructed linkage maps of the human chromosomes to use as a tool towards the goal of cloning by position the genes responsible for genetic disorders. Construction of the map required the development of polymorphic marker systems in the form of Restriction Fragment Length Polymorphisms (RFLPs). Work by Yusuke Nakamura in the laboratory led to the identification of more than 200 highly...
Topics
- Alleles
- Animals
- Base Sequence
- Biological Evolution
- Crossing Over, Genetic
- DNA, Satellite
- Genetic Linkage
- Genetic Markers
- Humans
- Molecular Sequence Data
- Polymorphism, Restriction Fragment Length