Article
Secretion signal of the filamentous haemagglutinin, a model two-partner secretion substrate.
Molecular microbiology - 1 Jul 2006
Hodak Hélène, Clantin Bernard, Willery Eve, Villeret Vincent, Locht Camille, Jacob-Dubuisson Françoise
Abstract excerpt
The sorting of proteins to their proper subcellular compartment requires specific addressing signals that mediate interactions with ad hoc transport machineries. In Gram-negative bacteria, the widespread two-partner secretion (TPS) pathway is dedicated to the secretion of large, mostly virulence-related proteins. The secreted TpsA proteins carry a characteristic 250-residue-long N-terminal 'TPS domain' essential...
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