Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comprehensive analysis of expression and function of 51 sarco(endo)plasmic reticulum Ca2+-ATPase mutants associated with Darier disease.

The Journal of biological chemistry - 11 Aug 2006

Miyauchi Yuki, Daiho Takashi, Yamasaki Kazuo, Takahashi Hidetoshi, Ishida-Yamamoto Akemi, Danko Stefania, Suzuki Hiroshi, Iizuka Hajime

Abstract excerpt

We examined possible defects of sarco(endo)plasmic reticulum Ca2+-ATPase 2b (SERCA2b) associated with its 51 mutations found in Darier disease (DD) pedigrees, i.e. most of the substitution and deletion mutations of residues reported so far. COS-1 cells were transfected with each of the mutant cDNAs, and the expression and function of the SERCA2b protein was analyzed with microsomes prepared from the cells and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Calcium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium-Transporting ATPases

Share to Chlorocebus aethiops

Share to COS Cells

Share to Darier Disease

Share to Molecular Conformation

Share to Sarcoplasmic Reticulum Calcium-Transporting ATPases

Source

Identifiers

PMID: 16766529
DOI: 10.1074/jbc.M601966200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive analysis of expression and function of 51 sarco(endo)plasmic reticulum Ca2+-ATPase mutants associated with Darier disease.PMID 16766529Read ↗

Dissection of the functional differences between sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) 1 and 2 isoforms and characterization of Darier disease (SERCA2) mutants by steady-state and transient kinetic analyses.Semantic proximity Read ↗

Distinct types of abnormality in kinetic properties of three Darier disease-causing sarco(endo)plasmic reticulum Ca2+-ATPase mutants that exhibit normal expression and high Ca2+ transport activity.Semantic proximity Read ↗

Multiple effects of SERCA2b mutations associated with Darier's disease.Semantic proximity Read ↗

Mutations in the Sarcoplasmic/Endoplasmic Reticulum Ca2+ ATPase Isoform Cause Darier's DiseaseSemantic proximity Read ↗

A Darier disease mutation relieves kinetic constraints imposed by the tail of sarco(endo)plasmic reticulum Ca2+-ATPase 2b.Semantic proximity Read ↗

P160L mutation in the Ca(2+) ATPase 2A domain in a patient with severe Darier disease.Semantic proximity Read ↗

Deletions of any single residues in Glu40-Ser48 loop connecting a domain and the first transmembrane helix of sarcoplasmic reticulum Ca(2+)-ATPase result in almost complete inhibition of conformational transition and hydrolysis of phosphoenzyme intermediate.Semantic proximity Read ↗

Mutation analysis of the ATP2A2 gene in Taiwanese patients with Darier's disease.Semantic proximity Read ↗

Darier Disease - A Multi-organ Condition?Semantic proximity Read ↗

Protein aggregation of SERCA2 mutants associated with Darier disease elicits ER stress and apoptosis in keratinocytes.Semantic proximity Read ↗

Novel mutations of ATP2A2 gene in Japanese patients of Darier's disease.Semantic proximity Read ↗

An ATP2A2 Missense Mutation in a Japanese Family with Darier Disease: A Case Report and Review of the Japanese Darier Disease Patients with ATP2A2 Mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.