Article
Single-gene mutations and increased left ventricular wall thickness in the community: the Framingham Heart Study.
Circulation - 13 Jun 2006
Morita Hiroyuki, Larson Martin G, Barr Scott C, Vasan Ramachandran S, O'Donnell Christopher J, Hirschhorn Joel N, Levy Daniel, Corey Diane, Seidman Christine E, Seidman J G, Benjamin Emelia J
Abstract excerpt
BACKGROUND: Mutations in sarcomere protein, PRKAG2, LAMP2, alpha-galactosidase A (GLA), and several mitochondrial genes can cause rare familial cardiomyopathies, but their contribution to increased left ventricular wall thickness (LVWT) in the community is unknown. METHODS AND RESULTS: We studied 1862 unrelated participants (52% women; age, 59+/-9 years) from the community-based Framingham Heart Study who had...
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