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Defining Virulence Genes in the Dimorphic Fungi

5 Jun 2006

Abstract excerpt

Most dimorphic fungal pathogens cause respiratory disease in mammals and must therefore possess virulence mechanisms to combat and overcome host pulmonary defenses. Over the past decade, advances in genetic tools have made it possible to investigate the basis of dimorphic fungal pathogenesis at the molecular level. Gene disruptions and RNA interference have now formally demonstrated the involvement of six...

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PMID: 16753032
DOI: 10.1146/annurev.micro.59.030804.121055

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