Article
Clinicopathologic and genetic analysis of siblings with NF1 and adult-onset gliomas.
Journal of the neurological sciences - 15 Aug 2006
Hariharan Subramanian, Donahue John E, Garre Cecial, Origone Paola, Grewal Raji P
Abstract excerpt
BACKGROUND: Neurofibromatosis Type 1 (NF1) is a common autosomal dominant neurogenetic disorder characterized by neoplasms involving the nervous system which typically present in children. The development of intracranial tumors in adults with NF1 is uncommon and to our knowledge, siblings with adult onset gliomas have not been previously reported. OBJECTIVE: To perform pathological, clinical and genetic analysis...
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