Article
Parent-of-origin in individuals with familial neurofibromatosis type 1 and optic pathway gliomas.
Familial cancer - 1 Dec 2012
Johnson K J, Fisher M J, Listernick R L, North K N, Schorry E K, Viskochil D, Weinstein M, Rubin J B, Gutmann D H
Abstract excerpt
Neurofibromatosis type 1 (NF1) is one of the most common autosomal dominant cancer syndromes worldwide. Individuals with NF1 have a wide variety of clinical features including a strongly increased risk for pediatric brain tumors. The etiology of pediatric brain tumor development in NF1 is largely unknown. Recent studies have highlighted the contribution of parent-of-origin effects to tumorigenesis in sporadic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.