Article
Fetal growth restriction: pathogenic mechanisms.
Clinical obstetrics and gynecology - 1 Jun 2006
Maulik Dev, Frances Evans Jodi, Ragolia Louis
Abstract excerpt
Complex genetic and environmental mechanisms of maternal, fetal and placental origin regulate fetal growth and may contribute to fetal growth restriction (FGR). The somatotrophic regulatory factors include IGF-I, IGF-II, the IGF binding proteins (IGFBP) 1-6, IGF receptors 1 and 2, and the IGFBP specific proteases. Abnormal remodeling of utero-placental arteries and abnormal fetal-placental angiogenesis has also...
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