Article
Use of immunoglobulin gene rearrangements to show clonal lymphoproliferation in hyper-reactive malarial splenomegaly.
Lancet (London, England) - 2 Mar 1991
Bates I, Bedu-Addo G, Bevan D H, Rutherford T R
Abstract excerpt
In Africa, hyper-reactive malarial splenomegaly (HMS), which is also known as tropical splenomegaly syndrome, can be associated with a prominent lymphocytosis in blood and bone marrow that is difficult to distinguish clinically from chronic lymphocytic leukaemia (CLL). The observation that some p...
Topics
- Adolescent
- Adult
- Aged
- Animals
- Child
- DNA Probes
- Drug Resistance
- Evaluation Studies as Topic
- Female
- Gene Rearrangement, T-Lymphocyte
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell
- Lymphocytosis
- Malaria
- Male
- Middle Aged
- Mutation
- Plasmodium falciparum