Article
Morbillivirus nucleoprotein possesses a novel nuclear localization signal and a CRM1-independent nuclear export signal.
Virology - 15 Aug 2006
Sato Hiroki, Masuda Munemitsu, Miura Ryuichi, Yoneda Misako, Kai Chieko
Abstract excerpt
Morbilliviruses, which belong to the Mononegavirales, replicate its RNA genome in the cytoplasm of the host cell. However, they also form characteristic intranuclear inclusion bodies, consisting of nucleoprotein (N), in infected cells. To analyze the mechanisms of nucleocytoplasmic transport of N protein, we characterized the nuclear localization (NLS) and nuclear export (NES) signals of canine distemper virus...
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