Genome microevolution of chikungunya viruses causing the Indian Ocean outbreak.

doi:10.1371/journal.pmed.0030263

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Article

Genome microevolution of chikungunya viruses causing the Indian Ocean outbreak.

PLoS medicine - 1 Jul 2006

Schuffenecker Isabelle, Iteman Isabelle, Michault Alain, Murri Séverine, Frangeul Lionel, Vaney Marie-Christine, Lavenir Rachel, Pardigon Nathalie, Reynes Jean-Marc, Pettinelli François, Biscornet Leon, Diancourt Laure, Michel Stéphanie, Duquerroy Stéphane, Guigon Ghislaine, Frenkiel Marie-Pascale, Bréhin Anne-Claire, Cubito Nadège, Desprès Philippe, Kunst Frank, Rey Félix A, Zeller Hervé, Brisse Sylvain

Abstract excerpt

BACKGROUND: A chikungunya virus outbreak of unprecedented magnitude is currently ongoing in Indian Ocean territories. In Réunion Island, this alphavirus has already infected about one-third of the human population. The main clinical symptom of the disease is a painful and invalidating poly-arthralgia. Besides the arthralgic form, 123 patients with a confirmed chikungunya infection have developed severe clinical...

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PMID: 16700631
DOI: 10.1371/journal.pmed.0030263
PMCID: PMC1463904

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