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Article

Physical and functional association of human protein O-mannosyltransferases 1 and 2.

The Journal of biological chemistry - 14 Jul 2006

Akasaka-Manya Keiko, Manya Hiroshi, Nakajima Ai, Kawakita Masao, Endo Tamao

Abstract excerpt

A defect of protein O-mannosylation causes congenital muscular dystrophy with brain malformation and structural eye abnormalities, so-called Walker-Warburg syndrome. Protein O-mannosylation is catalyzed by protein O-mannosyltransferase 1 (POMT1) and its homologue, POMT2. Coexpression of POMT1 and POMT2 is required to show O-mannosylation activity. Here we have shown that POMT1 forms a complex with POMT2 and the...

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Source

Identifiers

PMID: 16698797
DOI: 10.1074/jbc.M601091200

Genes

POMT1
POMT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Physical and functional association of human protein O-mannosyltransferases 1 and 2.PMID 16698797Read ↗

Mutations of the POMT1 gene found in patients with Walker–Warburg syndrome lead to a defect of protein O-mannosylationSemantic proximity Read ↗

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The expanding phenotype of POMT1 mutations: from Walker-Warburg syndrome to congenital muscular dystrophy, microcephaly, and mental retardation.Semantic proximity Read ↗

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