Article
A variant of the SYT-SSX2 fusion gene in a case of synovial sarcoma.
Cancer genetics and cytogenetics - 1 May 2006
Otsuka Seiji, Nishijo Koichi, Nakayama Tomitaka, Aoyama Tomoki, Ishibe Tatsuya, Shibata Kotaro R, Shima Yasuko, Nakamura Takashi, Otsuka Takanobu, Toguchida Junya
Abstract excerpt
Synovial sarcoma is a malignant soft tissue tumor harboring a tumor-specific fusion gene, SYT-SSX, of which exon 10 of the SYT gene is fused to exon 6 of the SSX gene is the common form. Here we report a case of synovial sarcoma with a novel form of the SYT-SSX2 fusion transcript, in which 75 bases were inserted at the common fusion junction. Computer analyses revealed that 15 bases were from intron 10 of the SYT...
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