Article
A cautionary note on the use of simulation procedures for analyzing contingency tables containing small expected cell frequencies.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jun 2006
Robles Jaime R, van den Oord Edwin J C G
Abstract excerpt
A comparison of a simple simulation procedure and exact tests for tables used in psychiatric genetic studies is performed, with focus on tables with small expected cell counts. The study shows that naive simulation procedures using uniform random numbers, could lead to conservative results, as compared with Fisher exact test for contingency tables, thus discarding as non-significant tables that are significant...
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