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Article

Breakpoint cloning and haplotype analysis indicate a single origin of the common Inv(10)(p11.2q21.2) mutation among northern Europeans.

American journal of human genetics - 1 May 2006

Gilling Mette, Dullinger Jörn S, Gesk Stefan, Metzke-Heidemann Simone, Siebert Reiner, Meyer Thomas, Brondum-Nielsen Karen, Tommerup Niels, Ropers Hans-Hilger, Tümer Zeynep, Kalscheuer Vera M, Thomas N Simon

Abstract excerpt

The pericentric inv(10)(p11.2q21.2) mutation has been frequently identified in cytogenetic laboratories, is phenotypically silent, and is considered to be a polymorphic variant. Cloning and sequencing of the junction fragments on 10p11 and 10q21 revealed that neither inversion breakpoint directly involved any genes or repetitive sequences, although both breakpoint regions contain a number of repeats. All 20...

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PMID: 16642442
DOI: 10.1086/503632
PMCID: PMC1474032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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