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Article

Predicting deleterious nsSNPs: an analysis of sequence and structural attributes.

BMC bioinformatics - 21 Apr 2006

Dobson Richard J, Munroe Patricia B, Caulfield Mark J, Saqi Mansoor As

Abstract excerpt

BACKGROUND: There has been an explosion in the number of single nucleotide polymorphisms (SNPs) within public databases. In this study we focused on non-synonymous protein coding single nucleotide polymorphisms (nsSNPs), some associated with disease and others which are thought to be neutral. We describe the distribution of both types of nsSNPs using structural and sequence based features and assess the relative...

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Identifiers

PMID: 16630345
DOI: 10.1186/1471-2105-7-217
PMCID: PMC1489951

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