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Article

Space Asymmetry Directs Preferential Sperm Entry in the Absence of Polarity in the Mouse Oocyte

18 Apr 2006

Abstract excerpt

Knowledge about the mechanism that establishes embryonic polarity is fundamental in understanding mammalian development. In re-addressing several controversial claims, we recently proposed a model in which mouse embryonic polarity is not specified until the blastocyst stage. Before fertilization, the fully differentiated oocyte has been characterized as "polarized," and we indeed observed that the sperm...

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PMID: 16620153
DOI: 10.1371/journal.pbio.0040135

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