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Article

PIN proteins perform a rate-limiting function in cellular auxin efflux.

Science (New York, N.Y.) - 12 May 2006

Petrásek Jan, Mravec Jozef, Bouchard Rodolphe, Blakeslee Joshua J, Abas Melinda, Seifertová Daniela, Wisniewska Justyna, Tadele Zerihun, Kubes Martin, Covanová Milada, Dhonukshe Pankaj, Skupa Petr, Benková Eva, Perry Lucie, Krecek Pavel, Lee Ok Ran, Fink Gerald R, Geisler Markus, Murphy Angus S, Luschnig Christian, Zazímalová Eva, Friml Jirí

Abstract excerpt

Intercellular flow of the phytohormone auxin underpins multiple developmental processes in plants. Plant-specific pin-formed (PIN) proteins and several phosphoglycoprotein (PGP) transporters are crucial factors in auxin transport-related development, yet the molecular function of PINs remains unknown. Here, we show that PINs mediate auxin efflux from mammalian and yeast cells without needing additional...

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PMID: 16601150
DOI: 10.1126/science.1123542

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PGP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

PIN proteins perform a rate-limiting function in cellular auxin efflux.PMID 16601150Read ↗

Subcellular homeostasis of phytohormone auxin is mediated by the ER-localized PIN5 transporter.Semantic proximity Read ↗

Interactions among PIN-FORMED and P-glycoprotein auxin transporters in Arabidopsis.Semantic proximity Read ↗

Antagonistic regulation of PIN phosphorylation by PP2A and PINOID directs auxin flux.Semantic proximity Read ↗

Cross-species functional diversity within the PIN auxin efflux protein family.Semantic proximity Read ↗

PIN phosphorylation is sufficient to mediate PIN polarity and direct auxin transport.Semantic proximity Read ↗

A PINOID-dependent binary switch in apical-basal PIN polar targeting directs auxin efflux.Semantic proximity Read ↗

Relocalization of the PIN1 auxin efflux facilitator plays a role in phototropic responses.Semantic proximity Read ↗

The endoplasmic reticulum localized PIN8 is a pollen-specific auxin carrier involved in intracellular auxin homeostasis.Semantic proximity Read ↗

Auxin efflux by PIN-FORMED proteins is activated by two different protein kinases, D6 PROTEIN KINASE and PINOID.Semantic proximity Read ↗

Arabidopsis Flippases Cooperate with ARF GTPase Exchange Factors to Regulate the Trafficking and Polarity of PIN Auxin Transporters.Semantic proximity Read ↗

PATELLINS are regulators of auxin-mediated PIN1 relocation and plant development in Arabidopsis thaliana.Semantic proximity Read ↗

A dominant negative mutant of protein kinase CK2 exhibits altered auxin responses in Arabidopsis.Semantic proximity Read ↗

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